LymphedemaV1, Main, Exploration, bibRecord, 004F27

Effect of annual mass administration of diethylcarbamazine and albendazole on bancroftian filariasis in five villages in south India.

Identifieur interne : 004F27 ( Main/Exploration ); précédent : 004F26; suivant : 004F28

Effect of annual mass administration of diethylcarbamazine and albendazole on bancroftian filariasis in five villages in south India.

Auteurs : K D Ramaiah [Inde] ; P. Vanamail ; J. Yuvaraj ; P K Das

Source :

Transactions of the Royal Society of Tropical Medicine and Hygiene [ 1878-3503 ] ; 2011.

RBID : pubmed:21601901

Descripteurs français

KwdFr :
- Albendazole (administration et posologie), Animaux, Antigènes d'helminthe (), Antigènes d'helminthe (immunologie), Calendrier d'administration des médicaments, Culex, Diéthylcarbamazine (administration et posologie), Femelle, Filaricides (administration et posologie), Filariose lymphatique (immunologie), Filariose lymphatique (traitement médicamenteux), Filariose lymphatique (épidémiologie), Humains, Inde (épidémiologie), Microfilaria (), Microfilaria (immunologie), Mâle, Prévalence, Santé en zone rurale, Wuchereria bancrofti (), Wuchereria bancrofti (immunologie).
MESH :
- administration et posologie : Albendazole, Diéthylcarbamazine, Filaricides.
- immunologie : Antigènes d'helminthe, Filariose lymphatique, Microfilaria, Wuchereria bancrofti.
- traitement médicamenteux : Filariose lymphatique.
- épidémiologie : Filariose lymphatique, Inde.
- Animaux, Antigènes d'helminthe, Calendrier d'administration des médicaments, Culex, Femelle, Humains, Microfilaria, Mâle, Prévalence, Santé en zone rurale, Wuchereria bancrofti.

English descriptors

KwdEn :
- Albendazole (administration & dosage), Animals, Antigens, Helminth (drug effects), Antigens, Helminth (immunology), Culex, Diethylcarbamazine (administration & dosage), Drug Administration Schedule, Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (epidemiology), Elephantiasis, Filarial (immunology), Female, Filaricides (administration & dosage), Humans, India (epidemiology), Male, Microfilariae (drug effects), Microfilariae (immunology), Prevalence, Rural Health, Wuchereria bancrofti (drug effects), Wuchereria bancrofti (immunology).
MESH :
- chemical , administration & dosage : Albendazole, Diethylcarbamazine, Filaricides.
- chemical , drug effects : Antigens, Helminth.
- chemical , immunology : Antigens, Helminth.
- drug effects : Microfilariae, Wuchereria bancrofti.
- drug therapy : Elephantiasis, Filarial.
- epidemiology : Elephantiasis, Filarial, India.
- immunology : Elephantiasis, Filarial, Microfilariae, Wuchereria bancrofti.
- Animals, Culex, Drug Administration Schedule, Female, Humans, Male, Prevalence, Rural Health.

Abstract

Annual mass drug administration (MDA) is the recommended strategy for lymphatic filariasis (LF) elimination. We assessed the effect of six rounds of mass administration of diethylcarbamazine (DEC) and albendazole (ALB) on microfilaria (Mf) prevalence and intensity and vector infection and infectivity rates and circulating filarial antigenaemia (CFA) in a group of five villages in south India, endemic for Culex-transmitted bancroftian filariasis. During different rounds of MDA, 60-70% of the eligible population (>15 kg body weight) was treated. The MDA reduced the Mf prevalence from 8.10% (CI 6.18-10.01) to 1.01% (CI 0.31-1.71) (P<0.05) and geometric mean intensity of Mf from 0.31 (CI 0.22-0.40) to 0.02 (CI 0.00-0.04) (P<0.05), equivalent to a fall of 86% and 94% respectively. The vector infection and infectivity rates declined from 13.11% (CI 11.52-14.70) to 0.78% (CI 0.16-1.40) (P<0.05) and 1.04% (CI 0.56-1.52) to 0.13% (CI 0.00-0.39) (P<0.05), respectively. Four out of the five villages recorded <0.5% Mf prevalence and 0% vector infection rate. Circulating filarial antigenaemia (CFA) fell by 86% in the total population and 100% in 1-10 year old children. One of the five villages, which showed the highest baseline vector infection rate, showed >1.0% Mf rate. The results suggest that six rounds of mass administration of DEC and ALB, with 60-70% treatment coverage, is likely to achieve total interruption of transmission and elimination of LF in the majority of villages.

DOI: 10.1016/j.trstmh.2011.04.006
PubMed: 21601901

Affiliations:

Inde

Le document en format XML

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<term>Wuchereria bancrofti (immunologie)</term>
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<front><div type="abstract" xml:lang="en">Annual mass drug administration (MDA) is the recommended strategy for lymphatic filariasis (LF) elimination. We assessed the effect of six rounds of mass administration of diethylcarbamazine (DEC) and albendazole (ALB) on microfilaria (Mf) prevalence and intensity and vector infection and infectivity rates and circulating filarial antigenaemia (CFA) in a group of five villages in south India, endemic for Culex-transmitted bancroftian filariasis. During different rounds of MDA, 60-70% of the eligible population (>15 kg body weight) was treated. The MDA reduced the Mf prevalence from 8.10% (CI 6.18-10.01) to 1.01% (CI 0.31-1.71) (P<0.05) and geometric mean intensity of Mf from 0.31 (CI 0.22-0.40) to 0.02 (CI 0.00-0.04) (P<0.05), equivalent to a fall of 86% and 94% respectively. The vector infection and infectivity rates declined from 13.11% (CI 11.52-14.70) to 0.78% (CI 0.16-1.40) (P<0.05) and 1.04% (CI 0.56-1.52) to 0.13% (CI 0.00-0.39) (P<0.05), respectively. Four out of the five villages recorded <0.5% Mf prevalence and 0% vector infection rate. Circulating filarial antigenaemia (CFA) fell by 86% in the total population and 100% in 1-10 year old children. One of the five villages, which showed the highest baseline vector infection rate, showed >1.0% Mf rate. The results suggest that six rounds of mass administration of DEC and ALB, with 60-70% treatment coverage, is likely to achieve total interruption of transmission and elimination of LF in the majority of villages.</div>
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Effect of annual mass administration of diethylcarbamazine and albendazole on bancroftian filariasis in five villages in south India.

Effect of annual mass administration of diethylcarbamazine and albendazole on bancroftian filariasis in five villages in south India.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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